Gene information
Official symbol CHRM1
Official full name cholinergic receptor muscarinic 1
Gene type protein-coding gene
Chromosome11q12.3
Gene familyCholinergic receptors muscarinic
Resources
Entrez Gene 1128
HGNC HGNC:1950
Ensembl ENSG00000168539
Vega OTTHUMG00000167765
UCSC uc001nwi.4
GO terms: 56 records
GO Description Category LogP Number of genes Detail
GO:0004435 phosphatidylinositol phospholipase C activity GO Molecular Functions -7.32266784 10 More
GO:0004629 phospholipase C activity GO Molecular Functions -6.96326292 10 More
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO Biological Processes -9.16710904 33 More
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO Biological Processes -11.6592522 24 More
GO:0007268 chemical synaptic transmission GO Biological Processes -4.44678751 35 More
GO:0007586 digestion GO Biological Processes -7.00342423 19 More
GO:0007589 body fluid secretion GO Biological Processes -11.5155091 20 More
GO:0016788 hydrolase activity, acting on ester bonds GO Molecular Functions -4.57583420 56 More
GO:0022600 digestive system process GO Biological Processes -8.16734280 17 More
GO:0030424 axon GO Cellular Components -6.14132550 54 More
GO:0030425 dendrite GO Cellular Components -4.55233052 48 More
GO:0032941 secretion by tissue GO Biological Processes -4.96271284 7 More
GO:0042391 regulation of membrane potential GO Biological Processes -15.0641346 59 More
GO:0042578 phosphoric ester hydrolase activity GO Molecular Functions -4.79997475 34 More
GO:0042734 presynaptic membrane GO Cellular Components -4.19875640 10 More
GO:0043269 regulation of ion transport GO Biological Processes -36.9814668 116 More
GO:0043679 axon terminus GO Cellular Components -2.06584249 11 More
GO:0044306 neuron projection terminus GO Cellular Components -2.47884900 13 More
GO:0045211 postsynaptic membrane GO Cellular Components -5.83105498 30 More
GO:0046903 secretion GO Biological Processes -18.5147167 70 More
GO:0050890 cognition GO Biological Processes -8.00500082 37 More
GO:0051222 positive regulation of protein transport GO Biological Processes -13.8994291 46 More
GO:0051223 regulation of protein transport GO Biological Processes -25.2801266 81 More
GO:0060078 regulation of postsynaptic membrane potential GO Biological Processes -2.74505261 11 More
GO:0060251 regulation of glial cell proliferation GO Biological Processes -8.90876897 12 More
GO:0060341 regulation of cellular localization GO Biological Processes -10.5933083 72 More
GO:0070201 regulation of establishment of protein localization GO Biological Processes -24.4831554 82 More
GO:0071417 cellular response to organonitrogen compound GO Biological Processes -26.3253267 90 More
GO:0095500 acetylcholine receptor signaling pathway GO Biological Processes -3.70345918 7 More
GO:0097060 synaptic membrane GO Cellular Components -5.94418548 20 More
GO:0097447 dendritic tree GO Cellular Components -4.82959150 49 More
GO:0098685 Schaffer collateral - CA1 synapse GO Cellular Components -5.81792293 14 More
GO:0098793 presynapse GO Cellular Components -4.56552653 42 More
GO:0098889 intrinsic component of presynaptic membrane GO Cellular Components -4.93822812 13 More
GO:0098916 anterograde trans-synaptic signaling GO Biological Processes -4.44678751 35 More
GO:0098926 postsynaptic signal transduction GO Biological Processes -3.73790071 8 More
GO:0098936 intrinsic component of postsynaptic membrane GO Cellular Components -4.76116234 10 More
GO:0098948 intrinsic component of postsynaptic specialization membrane GO Cellular Components -4.56568042 8 More
GO:0098960 postsynaptic neurotransmitter receptor activity GO Molecular Functions -2.86473787 9 More
GO:0098978 glutamatergic synapse GO Cellular Components -4.83590061 31 More
GO:0098984 neuron to neuron synapse GO Cellular Components -1.42277265 10 More
GO:0099055 integral component of postsynaptic membrane GO Cellular Components -4.91964814 10 More
GO:0099056 integral component of presynaptic membrane GO Cellular Components -4.69230219 12 More
GO:0099060 integral component of postsynaptic specialization membrane GO Cellular Components -4.68780123 8 More
GO:0099240 intrinsic component of synaptic membrane GO Cellular Components -5.23284212 12 More
GO:0099536 synaptic signaling GO Biological Processes -6.00976162 42 More
GO:0099537 trans-synaptic signaling GO Biological Processes -5.17038357 38 More
GO:0099572 postsynaptic specialization GO Cellular Components -2.67743186 13 More
GO:0099634 postsynaptic specialization membrane GO Cellular Components -4.18233935 9 More
GO:0099699 integral component of synaptic membrane GO Cellular Components -4.78109966 11 More
GO:0150034 distal axon GO Cellular Components -2.90654836 23 More
GO:1901699 cellular response to nitrogen compound GO Biological Processes -26.9091664 96 More
GO:1903829 positive regulation of protein localization GO Biological Processes -12.9651258 57 More
GO:1904951 positive regulation of establishment of protein localization GO Biological Processes -13.0308630 46 More
GO:1905144 response to acetylcholine GO Biological Processes -4.09043632 8 More
GO:1905145 cellular response to acetylcholine GO Biological Processes -3.51698265 7 More
KEGG pathways: 4 records
KEGG Description Category LogP Number of genes Detail
hsa04020 Calcium signaling pathway KEGG Pathway -10.4415222 36 More
hsa04024 cAMP signaling pathway KEGG Pathway -7.78464854 30 More
hsa04080 Neuroactive ligand-receptor interaction KEGG Pathway -22.6219922 65 More
hsa04151 PI3K-Akt signaling pathway KEGG Pathway -29.3006421 73 More
Drug-Gene interaction
view
Related drugs: 84 records
Drug name Interaction type Source PMID View
aceclidine TTD view
aclidinium antagonist TdgClinicalTrial view
afacifenacin antagonist ChemblInteractions view
anisotropine methylbromide antagonist ChemblInteractions 20391952455546068973161713928417016423 view
arecoline agonist TTD 1713928417016423 view
asm-024 antagonist ChemblInteractions view
atropine antagonist DTCTdgClinicalTrialChemblInteractionsTEND 2306255078552171713928417016423 view
atropine sulfate antagonist ChemblInteractions view
benzquinamide antagonist TdgClinicalTrialTEND 1713928417016423 view
benztropine TdgClinicalTrialTENDTTD view
benztropine mesylate antagonist ChemblInteractions view
bethanechol agonist TdgClinicalTrialTEND 9224827 view
biperiden antagonist TdgClinicalTrialTENDTTD 808107110907719979880210370904117523521713928417016423 view
biperiden hydrochloride antagonist ChemblInteractions view
biperiden lactate antagonist ChemblInteractions view
buclizine inhibitorantagonist TdgClinicalTrialTEND 1713928417016423 view
carbachol agonist DTCTdgClinicalTrialTEND 150590342250796321930376 view
carbinoxamine TdgClinicalTrialTEND view
cevimeline agonist TdgClinicalTrialTEND 86240831713928417016423 view
cevimeline hydrochloride agonist ChemblInteractions view
clidinium antagonist TdgClinicalTrialTENDTTD 117523521713928417016423 view
clidinium bromide antagonist ChemblInteractions view
cyclopentolate antagonist TdgClinicalTrialTEND 2908542118482111713928417016423100251131799251719486927 view
cycrimine antagonist TdgClinicalTrialTENDTTD 1267542117523521713928417016423 view
cycrimine hydrochloride antagonist ChemblInteractions view
darotropium bromide antagonist ChemblInteractions view
desipramine antagonist TdgClinicalTrialTEND 78552171713928417016423 view
dicyclomine antagonist TdgClinicalTrialTENDTTD 19533734117523521713928417016423 view
dicyclomine hydrochloride antagonist ChemblInteractions view
diphemanil methylsulfate antagonist ChemblInteractions view
diphenidol antagonist TdgClinicalTrialTEND 18635231713928417016423 view
diphenidol hydrochloride antagonist ChemblInteractions view
doxepin antagonist TdgClinicalTrial 19179941214100078552172329499 view
ethopropazine antagonist TdgClinicalTrialTEND 223689729041171175235217016423 view
ethopropazine hydrochloride antagonist ChemblInteractions view
fesoterodine antagonist TEND 12076307 view
flavoxate antagonist TdgClinicalTrialTEND 17139284170164233247311 view
glycopyrrolate antagonist TdgClinicalTrialChemblInteractionsTENDTTD view
glycopyrronium antagonist TdgClinicalTrial 8249551117523521713928417016423 view
hexocyclium methylsulfate antagonist ChemblInteractions view
indacaterol TdgClinicalTrial view
ipratropium antagonist TdgClinicalTrialTEND 159872372854638130085570 view
isopropamide iodide antagonist ChemblInteractions view
levomepromazine antagonist TdgClinicalTrialTEND 28707162899826 view
mepenzolate bromide antagonist ChemblInteractions view
methantheline antagonist TdgClinicalTrialTEND 299383051713928417016423 view
methixene antagonist TdgClinicalTrialTENDTTD 1260817248661691431514817139284170164235330346 view
methixene hydrochloride antagonist ChemblInteractions view
methscopolamine TdgClinicalTrialTEND view
methscopolamine bromide antagonist ChemblInteractions view
metoclopramide agonist TdgClinicalTrial 1646646315835479171392841701642321278804 view
n-desmethylclozapine allosteric modulator TTD view
nebracetam TTD view
ngx-267 TdgClinicalTrialTTD view
olanzapine antagonist TdgClinicalTrialTEND 17316700178489192503203010227113 view
oxybutynin antagonist TdgClinicalTrialTEND 20590605164069437620236172226781713928417016423 view
oxyphencyclimine antagonist TdgClinicalTrialTEND 142602317139284170164233247303 view
oxyphencyclimine hydrochloride antagonist ChemblInteractions view
oxyphenonium antagonist TdgClinicalTrialTENDTTD 3580704117523521713928417016423 view
oxyphenonium bromide antagonist ChemblInteractions view
pilocarpine agonist DTCTdgClinicalTrialChemblInteractionsTEND 18824613171392841701642325478907 view
pilocarpine hydrochloride agonist ChemblInteractions view
pipertramine DTC view
pipertramine amide DTC view
pirenzepine antagonist TdgClinicalTrialTENDTTD 1271709611752352 view
procyclidine antagonist TdgClinicalTrialTEND 206244202253700202791714260231713928417016423 view
procyclidine hydrochloride antagonist ChemblInteractions view
promazine antagonist TdgClinicalTrialTEND 191102001713928417016423 view
promethazine antagonist TdgClinicalTrialTEND 12476402 view
propantheline antagonist TdgClinicalTrialTENDTTD 2656175357271416080359117523521701642315337834 view
propantheline bromide antagonist ChemblInteractions view
propiomazine antagonist TdgClinicalTrialTEND 126786911904296919110200171392841701642314488364 view
scopolamine antagonist TdgClinicalTrialChemblInteractionsTEND 2039869214534362 view
solifenacin antagonist TdgClinicalTrialTEND 20590605190294291713928417016423 view
suxamethonium agonist TdgClinicalTrialTEND 104377101713928417016423 view
thiethylperazine TdgClinicalTrialTEND view
tiotropium antagonist TdgClinicalTrial 125824471018878511281822 view
tolterodine antagonist TdgClinicalTrialTEND 147698321713928417016423 view
tridihexethyl antagonist TdgClinicalTrialTEND 1713928417016423 view
tridihexethyl chloride antagonist ChemblInteractions view
triflupromazine antagonist TdgClinicalTrialTEND 41520541713928417016423 view
trihexyphenidyl antagonist TdgClinicalTrialTENDTTD 2432979176313841175235217139284199400217016423186858323208836 view
trihexyphenidyl hydrochloride antagonist ChemblInteractions view
trospium antagonist TdgClinicalTrialTEND 171392841701642315482001 view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
Chr11:62925978 hypomethylation epigenomics ischemic cardiac events[prognosis (bad)] myocardial infarction Thunders M et al. Epigenetics. 2019
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